Drug eruption - 薬疹
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ドイツの2022年Stiftung Warentestの結果では、ModelDermに対する消費者満足度は有料の遠隔医療相談よりもわずかに低いだけでした。
ドイツの2022年Stiftung Warentestの結果では、ModelDermに対する消費者満足度は有料の遠隔医療相談よりもわずかに低いだけでした。
薬疹 (Drug eruption) は、全身に影響を及ぼすことが特徴です。
relevance score : -100.0%
References薬疹として知られる、薬剤によって引き起こされる皮膚反応は、重篤になることがあります。severe cutaneous adverse drug reactions (SCARs) と呼ばれるこれらの重篤な反応は、生命を脅かすものと考えられています。Stevens-Johnson syndrome (SJS)、toxic epidermal necrolysis (TEN)、acute generalized exanthematous pustulosis (AGEP)、drug reaction with eosinophilia and systemic symptoms (DRESS) のような状態が含まれます。SCARs はまれですが、入院患者の約 2% が経験しています。
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
31歳の女性が、右足の甲に痛みのない赤い斑点ができ、皮膚科を受診しました。彼女は、ニキビ跡のピコ秒レーザー治療後、前日に doxycycline (100 mg) を 1 回服用しました。昨年、同じレーザー治療後に同量の doxycycline を服用した際、同じ部位で同様の症状が出たことがあります。彼女には特記すべき既往歴はなく、局所的または全身的な発熱などの他の症状は認められませんでした。
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Stevens-Johnson syndrome (SJS) と toxic epidermal necrolysis (TEN) は、重篤な皮膚反応の 2 つの形態であり、多形紅斑やブドウ球菌性熱傷皮膚症候群などの他の皮膚疾患や薬物反応とは異なります。SJS/TEN は稀で重篤な反応で、広範な皮膚や粘膜の損傷を引き起こし、しばしば全身症状を伴います。80％以上の症例で薬剤が原因とされています。
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
薬疹の診断は主に病歴と臨床所見で行われ、皮膚生検、血液検査、免疫学的検査が補助的に用いられることがあります。
発疹を起こしやすい薬剤の例として、抗生物質やその他の抗菌薬、サルファ剤、非ステロイド性抗炎症薬（NSAID）、悪性腫瘍の化学療法薬、抗けいれん薬、向精神薬などがあります。
○ 診断と治療
発熱（体温上昇）がある場合は、できるだけ早く医師の診察を受けてください。疑わしい薬剤は中止する必要があります（例：抗生物質、非ステロイド性抗炎症薬など）。受診前に、セチリジンやロラタジンなどの経口抗ヒスタミン薬がかゆみや発疹の緩和に役立つことがあります。
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
血液検査（CBC、LFT、好酸球数）
医師の処方による経口ステロイド薬と抗ヒスタミン薬